energy storage efficiency of the tricarboxylic acid cycle
Случайные ссылки
A non-canonical tricarboxylic acid cycle underlies cellular identity
The tricarboxylic acid (TCA) cycle is a central hub of cellular metabolism, oxidizing nutrients to generate reducing equivalents for energy production and critical metabolites for...
Glutamate over-accumulation may serve as an endogenous indicator of tricarboxylic acid (TCA) cycle …
Glutamate over-accumulation may serve as an endogenous indicator of tricarboxylic acid (TCA) cycle suppression under NH 4 + nutrition in wheat (Triticum aestivum L.) seedlings Author links open overlay panel Feng Wang a b c, Jingwen Gao a c, Jean W.H. Yong c d, Yifei Liu c f, Dan Cao e, Xinhua He b c
Mid-infrared Photons Released by NAD+ Reduction in the Tricarboxylic …
Life can utilize energy with high efficiency, especially with the help of aerobic respiration, where the tricarboxylic acid (TCA) cycle acts as an important metabolic engine for mitochondria to produce the cell energy currency of adenosine triphosphate (ATP), and nicotinamide adenine dinucleotide (NAD) plays a particular role …
The Tricarboxylic Acid Cycle Metabolites for Cancer: Friend or …
The tricarboxylic acid (TCA) cycle is capable of providing sufficient energy for the physiological activities under aerobic conditions. Although tumor metabolic reprogramming places aerobic glycolysis in a dominant position, the TCA cycle remains indispensable for tumor cells as a hub for the metabolic linkage and interconversion of …
Determination of the intermediates in glycolysis and tricarboxylic acid ...
Effect of extraction solvents on the extraction efficiency of intracellular metabolites of the tricarboxylic acid cycle and glycolysis. Comparison of the extraction efficiency of the three extraction solvents: methanol-acetonitrile-water (4:4:2, v/v/v), 75%methanol-chloroform (9:1, v/v), 75%methanol-MTBE (9:1, v/v).
Regulation and function of the mammalian tricarboxylic acid cycle …
The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central metabolic pathway that performs the essential function of oxidizing nutrients to support cellular bioenergetics. More recently, it has become evident that TCA cycle behavior is dynamic, and products of the TCA cycle can be co-opted in cancer …
Mitochondrial TCA cycle metabolites control physiology and …
Recent evidence confers a new role for TCA cycle intermediates, generally thought to be important for biosynthetic purposes, as signaling molecules with functions …
Regulation and function of the mammalian tricarboxylic acid cycle
The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central metabolic pathway that performs the essential function of oxidizing nutrients to support …
An optimized analytical method for cellular targeted
Intracellular energy transfer is through ATP, and the production of ATP is related to energy metabolism of cells, especially in the tricarboxylic acid (TCA) cycle and glycolysis [10]. As two important metabolic pathways for energy metabolism, the TCA cycle is a metabolic process prevalent in living cells of aerobic organisms.
A long-lifetime aqueous organic redox flow battery utilizing multi ...
Abstract. High-volumetric-capacity and long-lifetime aqueous organic redox flow batteries (AORFBs) have received considerable attention for electrochemical energy storage. Here, we report a six-electron transfer π-conjugated heteroaromatic hexaazatrinaphthalene tricarboxylic acid (HATNTA) as a promising anolyte for AORFBs.
The Tricarboxylic Acid Cycle as a Central Regulator of the Rate of ...
In this review, these connections are explored in the light of the tricarboxylic acid (TCA) cycle specifically. The TCA cycle is fruitful ground because it is central to energy generation, integrates numerous aspects of cellular physiology, has broad signaling effects within and beyond the cell, [ 18 ] and alters its functioning in response to ...
The tricarboxylic acid (TCA) cycle: a malleable metabolic network …
The tricarboxylic acid (TCA) cycle is a primordial metabolic pathway that is conserved from bacteria to humans. Although this network is often viewed primarily as …
The citric acid cycle | Cellular respiration (article)
The citric acid cycle is a closed loop; the last part of the pathway reforms the molecule used in the first step. The cycle includes eight major steps. In the first step of the cycle, acetyl CoA combines with a four-carbon acceptor molecule, oxaloacetate, to form a six-carbon molecule called citrate. After a quick rearrangement, this six-carbon ...
Generation of an Escherichia coli strain growing on methanol via …
Here, we report the conversion of the industrial platform organism Escherichia coli into a synthetic methylotroph that assimilates methanol via the energy efficient ribulose monophosphate cycle. Methylotrophy is achieved after evolution of a methanol-dependent E. coli strain over 250 generations in continuous chemostat culture. …
9.1: Overview of the TCA Cycle
The TCA cycle ( t ri c arboxylic a cid cycle) is also called the citric acid cycle or, sometimes, the Krebs cycle. It takes up where glycolsis left off, improving the efficiency of respiration by extracting a little more energy to produce some more ATP. We should start by looking at a map of the cycle. When we left off, glycolysis had reached ...
A database of thermodynamic properties of the reactions of glycolysis, the tricarboxylic acid cycle…
A database of thermodynamic properties is developed, which extends a previous database of glycolysis and tricarboxylic acid cycle by adding the reactions of the pentose phosphate pathway. The raw data and documented estimations of solution properties are made electronically available.
The Simultaneous Determination of Tricarboxylic Acid Cycle …
The tricarboxylic acid (TCA) cycle has recently been in the spotlight in the field of oncology. Mutations in the enzymes called cytosolic isocitrate dehydrogenases (IDHs) are a common feature in several types of cancers and provide the enzyme with the new ability to catalyze α-ketoglutarate (αKG) to 2-hydroxyglutarate (2HG), which is now …
A citric acid cycle-deficient Escherichia coli as an efficient chassis …
Tricarboxylic acid cycle (TCA cycle) plays an important role for aerobic growth of heterotrophic bacteria. Theoretically, eliminating TCA cycle would decrease carbon dissipation and...
The Tricarboxylic Acid Cycle | SpringerLink
Named for its metabolism of the conjugate bases (citrate, isocitrate, and cis-aconitate) of three tricarboxylic acids in the early steps of the pathway, the Tricarboxylic Acid Cycle (or TCA cycle) is known simply as the Citric Acid Cycle.The term "cycle" refers to the fact that the initial six-carbon substrate (citrate) is oxidatively decarboxylated twice …
Energy Metabolism by the Yeast Cell | SpringerLink
The Citric Acid Cycle —also known as the Tricarboxylic Acid (TCA) Cycle and/or the Krebs cycle (Lowenstein 1969)—is basically a series of chemical reactions used by aerobic organisms (including yeast) to generate energy through the oxidation of acetyl-CoA derived from carbohydrates, fats and proteins (Fig. 6.22) into carbon dioxide and ...
Fermentative Production of Tricarboxylic Acid Cycle-Derived …
Overview: Engineering acid-tolerant yeast to consume cellulosic glucose and produce a TCA cycle-derived organic acid. Developing an integrated process from feedstock to purified chemical. Approach: Prototype strain demonstration in Year 1, transitioning to process optimization and integration in Year 2. Final validation based on process scaleup.
Assessment of plasma amino acids, purines, tricarboxylic acid cycle ...
The energy storage function of lipids can contribute to the synthesis and metabolism of uncontrolled growth of cancer cells. ... It is worth mentioning that, up to now, there is no targeted metabolomics analysis that simultaneously determine tricarboxylic acid cycle metabolites, amino acids, purines, and targeted lipidomics analysis for ...
Metabolic engineering and fermentation optimization strategies for producing organic acids of the tricarboxylic acid cycle …
Tricarboxylic acid (TCA) pathway is a ubiquitous metabolic pathway in living organisms that supplies energy and various metabolites for cellular activities.
Phenylalanine maintains the postharvest quality of ''Jinfeng'' pear fruit by modulating the tricarboxylic acid cycle …
Huang et al. (2022c) concluded that caffeic acid soaking lowered SDH activity and MdSDH expression, decreased respiration and maintained the storage quality of apples by restraining the TCA cycle. Similarly, CO 2 treatment inhibited the gene expression of SDH in pear fruit ( Wang et al., 2021b ).
High‐Rate Organic Cathode Constructed by …
Synthesis of Iron-Hexaazatrinaphthalene Tricarboxylic Acid Coordination Polymer. HATNTA (51.6 mg, 0.1 mmol), ferrous chloride tetrahydrate (198 mg, 1 mmol) and 1 mL 1 m hydrochloric acid were added in 10 mL DMAc to undergo a solvothermal reaction without stirring at 120 °C for 48 h. After cooling down, the dark …
Blocks in tricarboxylic acid cycle of Salmonella enterica
64 provides energy, as well as precursors for biosynthesis of a large number of biomolecules. In 65 particular, the tricarboxylic acid cycle (TCA cycle) produces the reductive equivalents for the 66 electron transport chain and the carbon backbone for various amino acids, making it an
Evidence and mechanism of biological formation of phosphine from the perspective of the tricarboxylic acid cycle …
Citric acid and L-malic acid are representative products involved in the tricarboxylic acid cycle, which are directly used as an energy matrix for microbe to produce phosphine. This study explored the relationship between phosphine and tricarboxylic acid cycle metabolites, and initially analyzed the mechanism by which …
Regulation and function of the mammalian tricarboxylic acid cycle
The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central metabolic pathway that performs the essential function of oxidizing nutrients …
Development of simultaneous quantitative analysis of tricarboxylic acid …
The tricarboxylic acid (TCA) cycle is one of the most important pathways of energy metabolism, and the profiles of its components are influenced by factors such as diseases and diets. Therefore, the differences in metabolic profile of TCA cycle between healthy and cancer cells have been the focus of studies to understand …